Florian Loher Selected Research

pralnacasan

7/2007	The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression.
2/2004	The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation.

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Florian Loher Research Topics

Disease

3	Colitis 07/2007 - 05/2003
1	Body Weight (Weight, Body) 07/2007
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/2004

Drug/Important Bio-Agent (IBA)

3	Dextran SulfateIBA 07/2007 - 05/2003
2	IceIBA 07/2007 - 02/2004
2	pralnacasanIBA 07/2007 - 02/2004
2	CytokinesIBA 07/2007 - 02/2004
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2007
1	Messenger RNA (mRNA)IBA 07/2007
1	Caspase 1 (ICE Protease)IBA 07/2007
1	ElementsIBA 07/2007
1	Interleukin-18 (Interleukin 18)IBA 02/2004
1	Drinking WaterIBA 02/2004
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 02/2004
1	InterleukinsIBA 02/2004
1	Interleukin-1beta (Interleukin 1 beta)IBA 02/2004
1	Phosphodiesterase InhibitorsIBA 05/2003
1	mesopramIBA 05/2003

Therapy/Procedure

1	Oral Administration 07/2007